Investigation of biocompatible polymer poly(caprolactone)- chitosan as nanolayer contain vitamin E with two methods of electrospinning and finishing
Keywords:
Polymer, Nanofiber, Electrospinning, Drug Delivery, Vitamin E.Abstract
One of the most necessary vitamins for human's body is vitamin E which many scientists investigated on release.
In this study, two new compatible polymer (POLYCAPROLACTON and CHITOSAN) have used in the same
time for creating a nano layer with this vitamin. Two methods of producing including electrospinning and
finishing have studied. For this purpose, various percentages of polycaprolacton and chitosan have combined
with vitamin E and produce with two methods. The surface morphology of nanofibers was studied by microscopy
(SEM). By using infrared spectrometer (FTIR) the links between vitamin and nanofiber were studied. The effects
of drug release and antimicrobial from nanofibers with standard (AATCC100) were measured. Based on the
results of tests it was found that nanofiber PCL-chitosan containing vitamin with a ratio of 70-30 and a
concentration of 1 gr and 0.3 gr that has produced with electrospinning, was shown the best speed and the best
release in compared to concentrations and the other ratios and the speed of electrospinning was more than
finishing and it had 81% Antimicrobial effects
